Ion Channels, Receptors, and Biosensors
Institut de Biologie Structurale, Grenoble
A postdoctoral position is available in the Laboratory of Membrane Proteins of the
Institute for Structural Biology (IBS) in Grenoble, France (www.ibs.fr)
We have devised a novel type of bio-inspired sensors, Ion-Channel Coupled Receptors
(ICCR), based on the fusion of receptors with an ion channel. Binding of a ligand to the
receptor triggers opening of the associated ion channel that is easily detectable using
standard electrophysiological techniques. This concept was validated by the creation of
ICCRs between a potassium channel and several G-protein coupled receptors (GPCR).
In collaboration with biochemists, bioinformaticians, and computer scientists, we are
now pursuing this work in several intertwined directions: structure-function study of
receptor-channel interactions in existing ICCRs, design and construction of new ICCRs,
mechanism of protein-protein interactions in natural ICCRs such as the K-ATP channel.
Although the project has obvious biotechnological applications, the approach shall
remain very fundamental with a strong focus on the structure and dynamics of
membrane proteins and on their interactions.
Moreau et al (2008) Nature Nanotech. 3:620-5
Vivaudou et al (2009) Structure and function of ATP-sensitive K+ channels In: Ion Channels: From
Structure to Function, Ed. J Kew & C Davies, Oxford University Press
Hosy et al (2010) J Biol Chem (in press)
We are looking for a motivated individual with a demonstrated experience in molecular
engineering and biophysics. A knowledge of electrophysiological recordings,
bioinformatics and/or membrane proteins will be an asset. At least one peer-reviewed
publication in a recognized international journal is absolutely required.
This position is available for 3 years starting as soon as possible, with possibility of a 1
year prolongation. Salary after tax ~2100€/month (~3000 US$). The project is funded by
the French Research Agency ANR.
Send CV with references to Dr Michel Vivaudou (e-mail: email@example.com)